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Family Guy
This animated series features the adventures of the Griffin family. Endearingly ignorant Peter and his stay-at-home wife, Lois, reside in Quahog, R.I., and have three kids. Meg, the eldest child, is a social outcast, and teenage Chris is awkward and clueless when it comes to the opposite sex. The youngest, Stewie, is a genius baby who is bent on killing his mother and destroying the world. Brian, the talking dog, keeps Stewie in check while sipping martinis and sorting through his own issues.
S9, EP1 "And Then There Were Fewer"
James Woods invites Quahog residents to his mansion, and the evening turns into a murder mystery when guests end up dead.
S16, EP13 "V Is for Mystery"
Stewie and Brian are detectives who embark on solving a string of mysterious murders set in Victorian-era London.
S4, EP17 "Fat Guy Strangler"
Lois learns she has a brother she has never met (Robert Downey Jr.), so she brings him home from a mental institution to live with her family.
S10, EP16 "Killer Queen"
Peter and Chris go to fat camp where they cross paths with a serial killer who targets overweight kids; an album cover frightens Stewie.
S21, EP6 "Happy Holo-ween"
Peter makes a hologram of himself to get out of menial household duties.